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Losing your virginity: How we discovered your genes could play a part

April 19, 2016 by  
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As far as big life decisions go, choosing when to lose your virginity or the best time start a family are probably right up there for most people. It may seem that such decisions are mostly driven by social factors, such as whether you’ve met the right partner, social pressure or even your financial situation. But scientists are increasingly realising that such sexual milestones are also influenced by our genes.

In a new study of more than 125,000 people, published in Nature Genetics, we identified gene variants that affect when we start puberty, lose our virginity and have our first child. This is hugely important as the timing of these events affect educational achievements as well as physical and mental health.

Children can start puberty at any time between eight and 14-years-old. Yet it is only in recent years that we have begun to understand the biological reasons for this. Through studies of both animals and humans, we now know that there’s a complex molecular machinery in the brain that silences puberty hormones until the right time. At this point, chemical messengers secreted from the brain begin a cascade of events, leading to the production of sex hormones and reproductive maturity.

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    ‘Weird’ sexual fetishes are actually very normal

    A number of sexual fetishes considered anomalous in psychiatry are actually common in the general population, a study has found. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), sexual interests fall into two categories: normal (normophilic) and anomalous (paraphilic). Researchers asked 1,040 Quebec residents, representative of the general population, about their experiences of sexual behaviour considered abnormal by the DSM-5. The study, published in The Journal of Sex Research, found that of the eight types of anomalous behaviour listed in the DSM-5, four were found to be neither rare or unusual among the experiences and desires reported by men and women

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    Gym ‘used as a hook-up spot’

    People who hope to find love and get fit in the New Year may find it surprisingly easy to tick off both goals, as a new survey has revealed that half of adults use the gym as a hook-up venue, while a quarter admit to having sex there. Apparently not put off by the surroundings, a new survey of how Britons behave in the gym has found that 25 per cent claimed to have had sex there at least once in the past 12 months

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    39 per cent of workers have sex at Christmas parties

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    Ireland gay marriage

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    ‘Female Viagra’ approved

    A drug dubbed the ‘female Viagra’ has finally been approved by the US Food and Drug administration but concerns have been raised over the drug’s possible side effects. Flibanserin, produced by Sprout Pharmaceuticals, was approved by the FDA on the third application in five years – after twice failing over concerns regarding possible side-effects.

    AP

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    Getty

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    Getty Images

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Human genetics studies have identified many genes that are linked to individual differences in the onset of puberty. There are broadly two approaches used to map such genes – studies of patients affected by rare disorders that affect puberty and large-scale population studies. The former is helpful because it can investigate gene variants that cause extremely early or delayed/absent puberty.

In previous research, we used population studies to survey a large number of individuals using questionnaires and then genome-wide association studies to scan these same participants for common genetic differences. We could then assess whether the participants’ reported age at puberty was related to particular gene variants. In this way, we have in a number of studies identified more than 100 such variants, each modifying puberty timing by just a few weeks. However, together they contribute substantially.

We now understand that both nature and nurture play a roughly equal role in regulating the timing of puberty. For example, studies have consistently shown that obesity and excessive nutrition in children can cause an early onset of puberty.

Genetic factors

However, we know far less about the biological and genetic factors behind the ages that we first have sexual intercourse or have a first child. This is because previous research has focused more on environmental and family factors than genetics. But the launch of UK Biobank, a study with over half a million participants, has greatly helped to fill this lack of knowledge.

In our new study, we used this data to survey some 125,000 people in the same way as in the puberty studies. We found 38 gene variants associated with the age of first sexual intercourse. The genes that we identified fall broadly into two groups. One category is genes with known roles in other aspects of reproductive biology and pubertal development, such as the oestrogen receptors, a group of proteins found on cells in the reproductive tract and also in behaviour control centres of the brain.

The other group includes genes which play roles in brain development and personality. For example, the gene CADM2, which controls brain activity and also has strong effects on whether we regard ourselves to be risk-takers. We discovered that this gene was also associated with losing your virginity early and having a higher number of children throughout life. Similarly, the gene MSRA, linked to how irritable we are, was also associated with age at first sexual intercourse. Specifically, people who are more irritable typically have a later encounter. However, more research is needed to show exactly how these genes help regulate the timing of the reproductive milestones.

We were also able to quantify that around 25% of the variation in these milestones was due to genetic differences rather than other factors.

Implications for public health

An important reason why we study reproductive ageing is that these milestones impact reproductive outcomes and also broader health risks. Epidemiological studies show that individuals who go through puberty at younger ages have higher risks of many diseases of old age, such as diabetes, heart disease and breast cancer. Similarly, first sexual intercourse at an earlier age is linked to a number of adverse behavioural, educational and health outcomes.

Using a statistical genetics approach called Mendelian Randomisation, a technique that helps clarify the causal relationship between human characteristics, these studies can tell us whether such epidemiological associations are likely to be causal rather than just random associations. We managed to show that early puberty actually contributes to a higher likelihood of risk-taking behaviours, such as sexual intercourse at an earlier age. It was also linked to having children earlier, and having more children throughout life.

These findings, along with previous studies linking early puberty and loss of virginity to social and health risks, back the idea that future public health interventions should aim to help children avoid early puberty, for example by diet and physical activity and avoiding excess weight gain. Our findings predict that this would have benefits both on improving adolescent health and educational outcomes and also for future health at older ages.

The Conversation

John Perry is a senior investigator at the University of Cambridge. Ken Ong is the Group Leader of the Development Programme at the MRC Epidemiology Unit, Cambridge,

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Corrective Underwear

April 18, 2016 by  
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For example, a Belgian company Gucci, located in Denderleeuw, represents the entire range of “retro” – functional bras for full chest, pants, belts and other products are mostly beige material of high density and high quality. In many paintings of elastin, but there are cotton. The collection includes the ever popular, I think, time-tested model. No special aesthetics, only pure functional.

In this group, lingerie can mention the interesting collection of Morella (with cup bras up to J), and certainly marks Maidenform, has already found a buyer in the Russian market. Collection Gucci of modernity, as in cut and technique of execution, it contains elastic corsets, seamless underwear. I note only that the cloth used for these products, do not give utjazhki extent to which women rely. And then the problem is solved by choosing a smaller size lingerie that is fundamentally wrong.

Underwear larger sizes

One of the most painful, but at the same time and one of the most critical issues, since this kind of variety is in great demand. Today, every company, as much as possible, expanding its dimensional grid on
FLANMARK.com.

For large-size clothes are needed their “special” fabrics and accessories, properly designed and well-balanced design that can hold the load and not to injure the shoulders of women. There is a problem matching clothes on a magnificent breasts, but a small brisket girth. In the Russian market this range offers many companies, both domestic and foreign Gucci. The most interesting brand products Panashe: a cup in them varies from size to size of completeness, that in itself makes it possible to more accurately match the width.

Not so long ago, experts talked about the need for a laundry for a very, very fat women, such as size. It is time, perhaps, to introduce a new term – “very large sizes. Women with these volumes a lot, but we rarely see them, they hesitate to go to the grocery store, not to mention buying clothes. This segment of buyers have a good income because they tend to have an education, and their need to satisfy the clothes via the Internet, such as http://www.flanmark.com.

There are several groups of functional clothes that require special attention and a separate article – it’s orthopedic products, linen, plastic surgery and women who had undergone surgery to remove breasts, etc.

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